{"id":143450,"date":"2024-10-14T13:33:10","date_gmt":"2024-10-14T17:33:10","guid":{"rendered":"https:/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450//www.ucf.edu/news/wp-json/wp/v2/posts/143450//news/news/wp-json/wp/v2/posts/143450//?p=143450"},"modified":"2025-06-17T14:42:27","modified_gmt":"2025-06-17T18:42:27","slug":"ucf-researchers-develop-unique-barcodes-for-molecules-to-help-expedite-medical-advancements","status":"publish","type":"post","link":"https:/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450//www.ucf.edu/news/wp-json/wp/v2/posts/143450//news/news/wp-json/wp/v2/posts/143450//ucf-researchers-develop-unique-barcodes-for-molecules-to-help-expedite-medical-advancements/news/wp-json/wp/v2/posts/143450//","title":{"rendered":"UCF Researchers Develop Unique /news/wp-json/wp/v2/posts/143450/u2018Barcodes/news/wp-json/wp/v2/posts/143450/u2019 for Molecules to Help Expedite Medical Advancements"},"content":{"rendered":"<p>Barcodes are commonly used to track items like groceries or clothing, but UCF researchers have developed a special /news/wp-json/wp/v2/posts/143450/u201cbarcode/news/wp-json/wp/v2/posts/143450/u201d to identify much smaller objects: molecules.</news/wp-json/wp/v2/posts/143450//p>/news/wp-json/wp/v2/posts/143450/n<p>UCF researchers, led by UCF&nbsp;<a href=/news/wp-json/wp/v2/posts/143450/"https:/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450//nanoscience.ucf.edu/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450/">NanoScience Technology Center</news/wp-json/wp/v2/posts/143450//a>&nbsp;Professor Debashis Chanda, developed a /news/wp-json/wp/v2/posts/143450/u201cbarcoding/news/wp-json/wp/v2/posts/143450/u201d technique to quickly identify chiral molecules based on their unique infrared fingerprints, potentially speeding up pharmaceutical and medical advancements.</news/wp-json/wp/v2/posts/143450//p>/news/wp-json/wp/v2/posts/143450/n<p>The molecules can be identified using a special pixelated 2D sensor array that interacts with precise light with the specific properties of the molecules to capture their unique vibrational absorptions, which are then mapped as a barcode.</news/wp-json/wp/v2/posts/143450//p>/news/wp-json/wp/v2/posts/143450/n<p>The study was funded by the U.S. National Science Foundation and was recently published in Advanced Materials.</news/wp-json/wp/v2/posts/143450//p>/news/wp-json/wp/v2/posts/143450/n<figure id=/news/wp-json/wp/v2/posts/143450/"attachment_143452/news/wp-json/wp/v2/posts/143450/" style=/news/wp-json/wp/v2/posts/143450/"max-width: 1200px;/news/wp-json/wp/v2/posts/143450/" class=/news/wp-json/wp/v2/posts/143450/"figure float-left/news/wp-json/wp/v2/posts/143450/"><noscript><img decoding=/news/wp-json/wp/v2/posts/143450/"async/news/wp-json/wp/v2/posts/143450/" width=/news/wp-json/wp/v2/posts/143450/"1200/news/wp-json/wp/v2/posts/143450/" height=/news/wp-json/wp/v2/posts/143450/"800/news/wp-json/wp/v2/posts/143450/" class=/news/wp-json/wp/v2/posts/143450/"figure-img size-full wp-image-143452 img-fluid/news/wp-json/wp/v2/posts/143450/" src=/news/wp-json/wp/v2/posts/143450/"https:/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450//www.ucf.edu/news/wp-json/wp/v2/posts/143450//wp-content/news/wp-json/wp/v2/posts/143450//blogs.dir/news/wp-json/wp/v2/posts/143450//20/news/wp-json/wp/v2/posts/143450//files/news/wp-json/wp/v2/posts/143450//2024/news/wp-json/wp/v2/posts/143450//10/news/wp-json/wp/v2/posts/143450//debashsis-2.jpg/news/wp-json/wp/v2/posts/143450/" alt=/news/wp-json/wp/v2/posts/143450/"UCF NanoScience Technology Center Professor Debashis Chanda is holding an assay for reading molecular barcodes. He and other UCF researchers recently developed this technology that has potential to expedite medical research and development. /news/wp-json/wp/v2/posts/143450/" srcset=/news/wp-json/wp/v2/posts/143450/"https:/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450//www.ucf.edu/news/wp-json/wp/v2/posts/143450//wp-content/news/wp-json/wp/v2/posts/143450//blogs.dir/news/wp-json/wp/v2/posts/143450//20/news/wp-json/wp/v2/posts/143450//files/news/wp-json/wp/v2/posts/143450//2024/news/wp-json/wp/v2/posts/143450//10/news/wp-json/wp/v2/posts/143450//debashsis-2.jpg 1200w, https:/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450//www.ucf.edu/news/wp-json/wp/v2/posts/143450//wp-content/news/wp-json/wp/v2/posts/143450//blogs.dir/news/wp-json/wp/v2/posts/143450//20/news/wp-json/wp/v2/posts/143450//files/news/wp-json/wp/v2/posts/143450//2024/news/wp-json/wp/v2/posts/143450//10/news/wp-json/wp/v2/posts/143450//debashsis-2-300x200.jpg 300w, https:/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450//www.ucf.edu/news/wp-json/wp/v2/posts/143450//wp-content/news/wp-json/wp/v2/posts/143450//blogs.dir/news/wp-json/wp/v2/posts/143450//20/news/wp-json/wp/v2/posts/143450//files/news/wp-json/wp/v2/posts/143450//2024/news/wp-json/wp/v2/posts/143450//10/news/wp-json/wp/v2/posts/143450//debashsis-2-768x512.jpg 768w, https:/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450//www.ucf.edu/news/wp-json/wp/v2/posts/143450//wp-content/news/wp-json/wp/v2/posts/143450//blogs.dir/news/wp-json/wp/v2/posts/143450//20/news/wp-json/wp/v2/posts/143450//files/news/wp-json/wp/v2/posts/143450//2024/news/wp-json/wp/v2/posts/143450//10/news/wp-json/wp/v2/posts/143450//debashsis-2-600x400.jpg 600w, https:/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450//www.ucf.edu/news/wp-json/wp/v2/posts/143450//wp-content/news/wp-json/wp/v2/posts/143450//blogs.dir/news/wp-json/wp/v2/posts/143450//20/news/wp-json/wp/v2/posts/143450//files/news/wp-json/wp/v2/posts/143450//2024/news/wp-json/wp/v2/posts/143450//10/news/wp-json/wp/v2/posts/143450//debashsis-2-360x240.jpg 360w/news/wp-json/wp/v2/posts/143450/" sizes=/news/wp-json/wp/v2/posts/143450/"(max-width: 1200px) 100vw, 1200px/news/wp-json/wp/v2/posts/143450/"></news/wp-json/wp/v2/posts/143450//noscript><img decoding=/news/wp-json/wp/v2/posts/143450/"async/news/wp-json/wp/v2/posts/143450/" width=/news/wp-json/wp/v2/posts/143450/"1200/news/wp-json/wp/v2/posts/143450/" height=/news/wp-json/wp/v2/posts/143450/"800/news/wp-json/wp/v2/posts/143450/" class=/news/wp-json/wp/v2/posts/143450/"figure-img size-full wp-image-143452 img-fluid lazyload/news/wp-json/wp/v2/posts/143450/" src=/news/wp-json/wp/v2/posts/143450/"data:image/news/wp-json/wp/v2/posts/143450//svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20800%22%3E%3C%2Fsvg%3E/news/wp-json/wp/v2/posts/143450/" alt=/news/wp-json/wp/v2/posts/143450/"UCF NanoScience Technology Center Professor Debashis Chanda is holding an assay for reading molecular barcodes. He and other UCF researchers recently developed this technology that has potential to expedite medical research and development. /news/wp-json/wp/v2/posts/143450/" srcset=/news/wp-json/wp/v2/posts/143450/"data:image/news/wp-json/wp/v2/posts/143450//svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20800%22%3E%3C%2Fsvg%3E 1200w/news/wp-json/wp/v2/posts/143450/" sizes=/news/wp-json/wp/v2/posts/143450/"(max-width: 1200px) 100vw, 1200px/news/wp-json/wp/v2/posts/143450/" data-srcset=/news/wp-json/wp/v2/posts/143450/"https:/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450//www.ucf.edu/news/wp-json/wp/v2/posts/143450//wp-content/news/wp-json/wp/v2/posts/143450//blogs.dir/news/wp-json/wp/v2/posts/143450//20/news/wp-json/wp/v2/posts/143450//files/news/wp-json/wp/v2/posts/143450//2024/news/wp-json/wp/v2/posts/143450//10/news/wp-json/wp/v2/posts/143450//debashsis-2.jpg 1200w, https:/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450//www.ucf.edu/news/wp-json/wp/v2/posts/143450//wp-content/news/wp-json/wp/v2/posts/143450//blogs.dir/news/wp-json/wp/v2/posts/143450//20/news/wp-json/wp/v2/posts/143450//files/news/wp-json/wp/v2/posts/143450//2024/news/wp-json/wp/v2/posts/143450//10/news/wp-json/wp/v2/posts/143450//debashsis-2-300x200.jpg 300w, https:/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450//www.ucf.edu/news/wp-json/wp/v2/posts/143450//wp-content/news/wp-json/wp/v2/posts/143450//blogs.dir/news/wp-json/wp/v2/posts/143450//20/news/wp-json/wp/v2/posts/143450//files/news/wp-json/wp/v2/posts/143450//2024/news/wp-json/wp/v2/posts/143450//10/news/wp-json/wp/v2/posts/143450//debashsis-2-768x512.jpg 768w, https:/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450//www.ucf.edu/news/wp-json/wp/v2/posts/143450//wp-content/news/wp-json/wp/v2/posts/143450//blogs.dir/news/wp-json/wp/v2/posts/143450//20/news/wp-json/wp/v2/posts/143450//files/news/wp-json/wp/v2/posts/143450//2024/news/wp-json/wp/v2/posts/143450//10/news/wp-json/wp/v2/posts/143450//debashsis-2-600x400.jpg 600w, https:/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450//www.ucf.edu/news/wp-json/wp/v2/posts/143450//wp-content/news/wp-json/wp/v2/posts/143450//blogs.dir/news/wp-json/wp/v2/posts/143450//20/news/wp-json/wp/v2/posts/143450//files/news/wp-json/wp/v2/posts/143450//2024/news/wp-json/wp/v2/posts/143450//10/news/wp-json/wp/v2/posts/143450//debashsis-2-360x240.jpg 360w/news/wp-json/wp/v2/posts/143450/" data-src=/news/wp-json/wp/v2/posts/143450/"https:/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450//www.ucf.edu/news/wp-json/wp/v2/posts/143450//wp-content/news/wp-json/wp/v2/posts/143450//blogs.dir/news/wp-json/wp/v2/posts/143450//20/news/wp-json/wp/v2/posts/143450//files/news/wp-json/wp/v2/posts/143450//2024/news/wp-json/wp/v2/posts/143450//10/news/wp-json/wp/v2/posts/143450//debashsis-2.jpg/news/wp-json/wp/v2/posts/143450/"><figcaption class=/news/wp-json/wp/v2/posts/143450/"figure-caption/news/wp-json/wp/v2/posts/143450/">UCF NanoScience Technology Center Professor Debashis Chanda is holding an assay for reading molecular barcodes. He and other UCF researchers recently developed this technology that has potential to expedite medical research and development. (Photo courtesy of Debashis Chanda)</news/wp-json/wp/v2/posts/143450//figcaption></news/wp-json/wp/v2/posts/143450//figure>/news/wp-json/wp/v2/posts/143450/n<p>Chiral molecules are pairs that are similar in structure but are twisted differently (left or right), like how a person/news/wp-json/wp/v2/posts/143450/u2019s left and right hands are mirror images of each other. Understanding the nature of chiral molecules is crucial to biological and pharmaceutical <a href=/news/wp-json/wp/v2/posts/143450/"https:/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450//www.ucf.edu/news/wp-json/wp/v2/posts/143450//research/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450/">research</news/wp-json/wp/v2/posts/143450//a> because the mirror image pairs&nbsp;<strong>/news/wp-json/wp/v2/posts/143450/u2014</news/wp-json/wp/v2/posts/143450//strong>&nbsp;known as enantiomers&nbsp;<strong>/news/wp-json/wp/v2/posts/143450/u2014</news/wp-json/wp/v2/posts/143450//strong>&nbsp;can each have different effects in the body or in chemical reactions.</news/wp-json/wp/v2/posts/143450//p>/news/wp-json/wp/v2/posts/143450/n<p>Nearly 56% of all modern drugs and medicine are chiral in nature, and about 90% of those are a mixture containing equal amounts of two enantiomers of a chiral compound. Researchers often face the challenge of separating enantiomers or synthesizing only the desired enantiomer to ensure optimal therapeutic outcomes and minimize adverse effects.</news/wp-json/wp/v2/posts/143450//p>/news/wp-json/wp/v2/posts/143450/n<p>Most modern medicines and drugs are chiral and are marketed as racemates (equal mixtures of enantiomers), which in some cases can have unwanted consequences, Chanda says. This highlights the need for techniques that can identify such molecules reliably and accurately.</news/wp-json/wp/v2/posts/143450//p>/news/wp-json/wp/v2/posts/143450/n<p>/news/wp-json/wp/v2/posts/143450/u201cOn molecular adsorption, the combined system/news/wp-json/wp/v2/posts/143450/u2019s response depends on the degree and positional overlap of the molecule/news/wp-json/wp/v2/posts/143450/u2019s absorbance and sensor resonance,/news/wp-json/wp/v2/posts/143450/u201d Chanda says. /news/wp-json/wp/v2/posts/143450/u201cThe measured signal is analyzed and encoded to generate a /news/wp-json/wp/v2/posts/143450/u2018chiral barcode/news/wp-json/wp/v2/posts/143450/u2019 for uniquely identifying the adsorbed chiral molecule. We show applicability of the platform by analyzing and generating unique chirality-based barcodes for an enantiomeric pair of small molecules, as well as a pair of spectrally similar larger chiral biomolecules based on very low volumes of analytes at ultra-low concentrations./news/wp-json/wp/v2/posts/143450/u201d</news/wp-json/wp/v2/posts/143450//p>/news/wp-json/wp/v2/posts/143450/n<p>The sensing platform is made of specially engineered nanopatterned gold where the interactions between the plasmonic and photonic cavity modes produce strong chiral /news/wp-json/wp/v2/posts/143450/u201csuperchiral/news/wp-json/wp/v2/posts/143450/u201d light, he says.</news/wp-json/wp/v2/posts/143450//p>/news/wp-json/wp/v2/posts/143450/n<p>By changing the geometrical parameters, 25 of such spectrally de-tuned sensors in 5&#215;5 array was produced. When a molecule is added to this array, each sensing element produces slightly different chiral response, resulting in a unique barcode.</news/wp-json/wp/v2/posts/143450//p>/news/wp-json/wp/v2/posts/143450/n<p>/news/wp-json/wp/v2/posts/143450/u201cUnlike other existing platforms that require chiral nanostructures of varying asymmetries that can be difficult to replicate, our proposed system/news/wp-json/wp/v2/posts/143450/u2019s inherent achirality overcomes this problem, greatly simplifying the fabrication process,/news/wp-json/wp/v2/posts/143450/u201d says <strong>Aritra Biswas /news/wp-json/wp/v2/posts/143450/u201912MS /news/wp-json/wp/v2/posts/143450/u201924PhD</news/wp-json/wp/v2/posts/143450//strong>, postdoctoral fellow and lead author of the paper. /news/wp-json/wp/v2/posts/143450/u201cAdditionally, the sensors are fabricated by simple nanoimprint lithography and two deposition steps, therefore making them very robust. We envision that such a versatile, low footprint, mass manufacturable platform would be a crucial tool for drug and biomolecular identification with applications in medical research and pharmaceutical industries./news/wp-json/wp/v2/posts/143450/u201d</news/wp-json/wp/v2/posts/143450//p>/news/wp-json/wp/v2/posts/143450/n<p>/news/wp-json/wp/v2/posts/143450/u201cWe aim to contribute towards the development of inexpensive and sensitive chiral drug identification methods for chemical, biological and medical research, the fabrication of novel devices exhibiting superior light-matter interaction and the demonstration of a real product with commercial viability,/news/wp-json/wp/v2/posts/143450/u201d Chanda says.</news/wp-json/wp/v2/posts/143450//p>/news/wp-json/wp/v2/posts/143450/n<p>Postdoctoral fellow Pablo Cencillo-Abad also contributed to the research and is listed as a study co-author.</news/wp-json/wp/v2/posts/143450//p>/news/wp-json/wp/v2/posts/143450/n<p>Those interested in licensing this technology may <a href=/news/wp-json/wp/v2/posts/143450/"https:/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450//ucf.flintbox.com/news/wp-json/wp/v2/posts/143450//technologies/news/wp-json/wp/v2/posts/143450//eadadb28-d504-4ddf-8fb6-72aa4e471459/news/wp-json/wp/v2/posts/143450/">learn more here</news/wp-json/wp/v2/posts/143450//a>.</news/wp-json/wp/v2/posts/143450//p>/news/wp-json/wp/v2/posts/143450/n<p><strong>Researcher/news/wp-json/wp/v2/posts/143450/u2019s Credentials:</news/wp-json/wp/v2/posts/143450//strong></news/wp-json/wp/v2/posts/143450//p>/news/wp-json/wp/v2/posts/143450/n<p>Chanda has joint appointments in UCF/news/wp-json/wp/v2/posts/143450/u2019s NanoScience Technology Center, Department of Physics and <a href=/news/wp-json/wp/v2/posts/143450/"https:/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450//creol.ucf.edu/news/wp-json/wp/v2/posts/143450///news/wp-json/wp/v2/posts/143450/">CREOL, the College of Optics and Photonics</news/wp-json/wp/v2/posts/143450//a>. He received his doctoral degree in photonics from the 海角直播 of Toronto and worked as a postdoctoral fellow at the 海角直播 of Illinois at Urbana-Champaign. He joined UCF in Fall 2012.</news/wp-json/wp/v2/posts/143450//p>/news/wp-json/wp/v2/posts/143450/n","protected":false},"excerpt":{"rendered":"<p>UCF NanoScience Technology Center researchers developed an easier way to identify unique molecules by their chiral spectral fingerprints, which could help in creating pharmaceuticals or biomolecules.</news/wp-json/wp/v2/posts/143450//p>/news/wp-json/wp/v2/posts/143450/n","protected":false},"author":8698,"featured_media":143454,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"lazy_load_responsive_images_disabled":false,"footnotes":"","_links_to":"","_links_to_target":"","_wp_rev_ctl_limit":""},"categories":[5,12,23,24],"tags":[981,1112,11131,14914,3279,14916],"tu_author":[],"class_list":["post-143450","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-colleges","category-health","category-research","category-science-technology","tag-college-of-optics-and-photonics","tag-creol","tag-debashis-chanda","tag-medicine","tag-nanoscience-technology-center","tag-research"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.3 (Yoast SEO v27.5) - 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NanoScience Technology Center researchers developed an easier way to identify unique molecules by their chiral spectral fingerprints, which could help in creating pharmaceuticals or 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NanoScience Technology Center Professor Debashis Chanda studies special nanoparticles to help people live better lives. Much of his research focuses on the interaction of molecules with different kinds of light to modify them to have different useful properties. (Photo by Antoine 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Researchers Develop Unique /news/wp-json/wp/v2/posts/143450/u2018Barcodes/news/wp-json/wp/v2/posts/143450/u2019 for Molecules to Help Expedite Medical 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